Objective. To evaluate the efficacy and safety of the Xen Gel Stent and provide a macro- and microscopic analyses of\nbleb morphology. Methods. A prospective 12-month study on patients with primary open-angle glaucoma. Patients\nunderwent implantation of the XEN Gel Stent (Allergan INC, Dublin, Ireland) either alone or combined with a\ncataract surgery. Biomicroscopy, in vivo confocal microscopy (IVCM), and anterior segment-optical coherence\ntomography (AS-OCT) were used to assess bleb morphology. Safety parameters were adverse events, best corrected visual\nacuity, visual field, and corneal endothelial cell loss. A postoperative IOP � 18mmHg without or on medications was\nrespectively defined as complete and qualified success while an IOP � 18mmHg was defined as failure. Results. Twelve\neyes of 11 patients were evaluated. At one year, 5 out of 10 patients available achieved a complete success while five\nwere qualified success. AS-OCT showed that bleb wall reflectivity was significantly higher in the failure group; IVCM\nrevealed that stromal density was significantly lower in the success group. No safety issues were recorded. Conclusion.\nImplantation of the XEN Gel Stent appears to be a safe and effective procedure. AS-OCT and IVCM may be helpful in\nbleb assessment.
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